Frequently Asked Questions
What is the Dynamic Gastric Model used for?
The DGM is used to study gastric digestion and formulation behaviour under dynamic, physiologically relevant in-vitro conditions.
What is the difference between the Dynamic Gastric Model and static dissolution models?
Static models operate under fixed conditions. The DGM reproduces time-dependent gastric processes such as changing pH, gastric emptying, and mechanical forces. Most alternative in vitro models provide only static or semi-dynamic conditions, which cannot fully reproduce the complexity of the human stomach. The DGM simulates the stomach’s hydrodynamics, biochemical composition, and peristaltic movements and can contain the full amount of meal, replicating exact clinical or pre-clinical protocol without needing to scale on dosage amount. This allows prediction of dosage form behaviour and drug dissolution under realistic gastro-intestinal conditions, supporting applications from bioequivalence and food-effect studies to complex modified-release systems, all with clinically relevant, non-animal data.
Who supplies the Dynamic Gastric Model units?
DGM units are supplied by Plant Bioscience Limited, UK, these are built to order for organisations wishing to own and operate the DGM in-house for research purposes.
Can training be provided?
Comprehensive training videos and manuals are supplied with purchase of the DGM, on-site training can be included as part of the installation and tailored to the client’s needs, please ask for details.
Can a service and maintenance package be purchased?
Yes, a service and maintenance package can be purchased separately, technical support can also be provided, please ask for details.
Who performs commercial services on the Dynamic Gastric Model?
Independent studies are conducted by Bioneer, a centre of excellence for gastro-intestinal (GI) modelling, please see Services.
Can Dynamic Gastric Model units be used without external services?
Yes, the DGM is a standalone unit that can be operated independently by the user.
What types of samples can be studied?
The model can be applied to a range of orally administered formulations and food matrices.
Where can I find examples of studies?
Examples of DGM studies are available in the Applications section.
How can I find out more?
We offer a free consultation to explore your needs, please contact us here.