The Dynamic Gastric Model (DGM) is a bench-top AI-driven in vitro system that simulates digestion in the human stomach, allowing accurate prediction and understanding of the behaviour of food or drug preparations in real time. The DGM has been utilised for oral pharmaceutical development and food digestion studies for over 20 years, and has been extensively validated against human in vivo studies. The DGM, which simulates the fundus/main body and the antrum of the human stomach, accurately replicates the complex biochemical composition and gastric forces crucial for prediction of the bio-behaviour of API’s (Active Pharmaceutical Ingredient’s) and dosage forms for oral delivery.
The DGM offers a physiologically relevant screening tool that provide's valuable data for evaluating novel and existing foodstuffs, diets and pharmaceutical preparations. The DGM provides an accurate and meaningful method for predicting the fate of compounds, nutrients and formulae prior to absorption and therefore will become an invaluable tool for mechanistic, stability and bioaccessibility studies during product development. The DGM can be applied to a wide range of product development, drug discovery and development projects, including those concerned with novel and functional foods, pharmaceutical delivery and bioavailability of active compounds and nutrients. Performance of reformulated products can be directly compared to original products as can performance of generic drugs to innovator drugs.
The DGM supports the acceleration of drug and food development, de-risking clinical trial failure through predictive bioavailability or bioequivalence and providing a fully validated alternative to animal studies.
Key Features
• Accurate replication of gastric processing parameters, representative gastric emptying and pH profiles, validated against measured in vivo human data
• Fed or Fasted state conditions simulated
• Automated dynamic adjustment of gastric acid and enzymes depending on food matrix
• Controllable gastric emptying and discharge, programable stomach to simulate a disease state
• Monitoring in real time and generation of detailed reports throughout the digestive process such as enzyme flow rate and pH
• Emptied samples can be utilised for downstream analysis or further digestion studies
Benefits
• The ability to investigate the digestion of both real foods and/or pharmaceutical preparations on the laboratory bench
• A large capacity allowing full multiphase meals to be assessed, including the “FDA breakfast”
• Allows sample collection at any time point from both the main body of the stomach and on exit from the antrum, allowing real time collection and detailed analysis
• Provides a physiological, cost effective and ethical alternative to the use of animal studies, supporting the FDA Modernisation Act 2.0
• Easy to clean, with minimum down time
• Fully automated, intuitive user interface
